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Tuesday, March 25, 2014

E-Cigarette Liquid Nicotine Poses Poison Risk

Yenisley Dieppa tries different flavors as she purchases an electronic cigarette at the Vapor Shark store on February 20, 2014 in Miami, Florida. New reports show that the liquid nicotine in e-cigarettes could be potentially lethal. (Joe Raedle/Getty Images)

Yenisley Dieppa tries different flavors as she purchases an electronic cigarette at the Vapor Shark store on February 20, 2014 in Miami, Florida. New reports show that the liquid nicotine in e-cigarettes could be potentially lethal. (Joe Raedle/Getty Images)

As e-cigarettes become more widespread, the nicotine liquid used to fill e-cigarettes has been found to be potentially dangerous.

Liquid nicotine is a neurotoxin and small amounts – whether ingested or absorbed through the skin – can be lethal.

As the New York Times reports, poison control centers around the country are seeing rising rates of accidental poisonings, especially among young children.

Here & Now’s Robin Young speaks with Ashley Webb, the director of the Kentucky Regional Poison Control Center, about whether she’s seen a rise in nicotine poisoning from e-cigarettes.

However, we heard from many Here & Now listeners who praised e-cigarettes for helping them quit traditional tobacco smoking.

Tom Glynn, director of Cancer Science and Trends at the American Cancer Society, says he’s intrigued by the promise of using e-cigarettes as a smoking cessation tool, but the scientific evidence – and the FDA – do not yet support the practice.

Interview Highlights: Tom Glynn and Ashley Webb

Webb on the main danger concerns related to e-cigarettes

“We’re concerned about children who get a hold of e-cigarettes or get a hold of the vials. One because they can spill it on their skin and have symptoms, or two because they can ingest it and have symptoms.

“But also adults who are handling e cigarettes or refilling e cigarettes have the potential to get it on their skin as well and have the same symptoms: nausea and vomiting, some pallor and sweating, salivation. We’ve seen a couple of cases with increased heart rate and blood pressure. We’re concerned that in a significant enough exposure we’d see cardiac affects and potentially nervous system affects including seizure.”

“We’re looking at such a high concentrated product that some amounts including just a milliliter to two milliliters can equal numerous cigarettes so we’ve seen calls for tobacco with children eating cigarettes and we do get a concern with that – but it takes a much smaller amount of the concentrated liquid to cause symptoms we’d be concerned about.”

Glynn on the American Cancer Society’s position on e-cigarettes

Our position on e-cigarettes are that they’re intriguing. In the short run, we know that they are going to be less harmful than a traditional burn cigarette; there’s virtually nothing that is more harmful than a traditional burn cigarette. And they may have a role in helping some smokers stop. But there are many, many scientific medical and social questions still surrounding e-cigarettes, and at this point we can’t actively encourage their use until we have more independent science-based information and FDA regulation.

Glynn on the debate over using FDA-approved cessation drugs and e-cigarettes

I’ve seen that argument for many years, and it’s just simply not the case. The FDA approved medications – all seven of them – five of them are nicotine replacement products, as well as two prescription products.

“They have been moderately useful: they help maybe on the first try, maybe 10 to 15 percent of people quit smoking. People then need to recycle and try again and they become more useful – particularly if they’re used correctly.

The limited data suggests that e-cigarettes are probably in the same range as the nicotine replacement products and the other two medications. So the question then arises: If they’re about equal, why use something that hasn’t been approved by the FDA? On the other hand – if they haven’t proved useful to someone – clinicians are not discouraging people from it — but basically saying do so with your eyes open.

Guests

Transcript

ROBIN YOUNG, HOST:

It's HERE AND NOW. In our recent report on e-cigarettes, both of our guests, Brian King of the Centers for Disease Control and Emily McDonald of the University of California San Francisco, were critical. E-cigs are not regulated, there's no research on the nicotine vapor they deliver, and there are studies that show they lead kids to real smoking.

But wait, many of you said, they helped me quit smoking. We want to get to that, but first a new concern about e-cigs, e-liquids, the pure nicotine extracted from tobacco that's the key ingredient in e-cigs. It's in refiller vials and in the e-cigs, and children are attracted to the sweetened flavors. In 2013, there were 74 e-cig poison cases just in Minnesota; 29 were kids under two.

We want to check in now in another state, Kentucky. Ashley Webb is a toxicologist and director of the Kentucky Regional Poison Control Center at Kosair Children's Hospital in Louisville. Ashley, what are you seeing there?

ASHLEY WEBB: We've already seen about 40 exposures this year. We look at trends, and so when you look at a number of nine in 2012 to over 60 in 2013, and now we're set to at least triple, if not more than that, in 2014, that that's an alarming trend for us.

YOUNG: Yes, it is. And you say exposures. E-liquids are far more dangerous than tobacco because it can be absorbed so quickly not just when it's ingested but on the skin.

WEBB: That's correct. So we're concerned about children who get a hold of e-cigarettes or get a hold of vials: One, because they can spill it on their skin and have symptoms; or two, because they can ingest it and have symptoms. But also adults who are handling e-cigarettes or refilling e-cigarettes have the potential to get it on their skin, as well, and have the same symptoms: nausea and vomiting, some pallor, sweating, salivation.

We've seen a couple of cases with increased heart rate and blood pressure. We're concerned that in a significant enough exposure we'd see cardiac effects and potentially nervous system effects including seizures.

YOUNG: Well, or death. We understand just a teaspoon of this nicotine could kill a small child.

WEBB: That's correct. We're looking at such a high concentrated product that some amounts, including just a milliliter to two milliliters, can equal numerous cigarettes. And so, you know, we've seen calls for tobacco with children eating cigarettes, and we do get concerned with that, but it takes a much smaller amount of the concentrated liquid to cause symptoms we'd be concerned about.

YOUNG: Well first of all, there's got to be awareness. Some people aren't even aware that this is true. But what else would you like to see happen here?

WEBB: We are trying to increase awareness that nicotine is a toxin and especially in a highly concentrated form, and we want people to recognize that they should treat it like a medication. They should keep it up and out of sight of children. And people using it themselves should use caution when refilling the product not to get nicotine on their skin.

YOUNG: Ashley Webb, toxicologist and director of the Kentucky Regional Poison Control Center at Kosair Children's Hospital there in Louisville, Kentucky. Ashley, thank you so much.

WEBB: Thank you for having me. Transcript provided by NPR, Copyright NPR.


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